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Why “Normal” Isn’t Always Optimal

  • Cherese Combs
  • Nov 18, 2025
  • 4 min read

Updated: Dec 3, 2025

Traditional medicine uses very wide reference ranges for hormones. These ranges are designed to flag extreme disease, not to identify the sweet spot where you feel energetic, sharp, and resilient. As a result, millions of men and women suffer needlessly while being told their labs look fine.


Hormone imbalances can stem from a variety of interconnected causes, disrupting your endocrine system and leading to a cascade of frustrating symptoms. For both men and women, chronic stress, thyroid dysfunction, poor diet, and nutrient deficiencies play major roles in throwing hormones out of sync. Aging naturally contributes too, but it's rarely the only factor – and the good news is, these imbalances are treatable with targeted optimization.


Understanding Hormonal Changes


Women don’t have to be menopausal to need help. Perimenopause – the transition phase that can begin in your 30s or even earlier after multiple pregnancies – brings a range of disruptive symptoms as estrogen, progesterone, and testosterone start to fluctuate.


Common signs include fatigue, unexplained weight gain, hot flashes, anxiety, low libido, and brain fog. These can intensify during full menopause, where symptoms like night sweats, mood swings, painful intercourse, and stubborn belly fat become even more persistent. Other triggers, such as polycystic ovary syndrome (PCOS), chronic stress, or thyroid issues, can mimic or exacerbate these effects, making everyday life feel overwhelming.



Men, meanwhile, face their own set of challenges often overlooked as "just getting older." Andropause – the male equivalent of menopause – involves a gradual testosterone decline starting in the 30s or 40s, but low T can strike at any age due to lifestyle, health conditions, or stress. This imbalance frequently causes fatigue, weight gain (especially around the midsection), reduced muscle mass, low energy, cognitive fog, diminished libido, and erectile dysfunction.



Compounding factors like metabolic syndrome (with insulin resistance, high blood pressure, and excess abdominal fat that boosts estrogen while tanking testosterone), adrenal dysfunction from chronic stress (leading to cortisol spikes or crashes), and even hypothyroidism can create a vicious cycle, stealing your drive and vitality.


The Real Risks of Suboptimal Hormones


Living with low or imbalanced hormones isn’t just uncomfortable – it’s dangerous. Decades of research link hormone deficiency and imbalance to higher rates of:


  • Breast cancer and uterine cancer (in women with unopposed estrogen)

  • Prostate cancer (in men with low testosterone or high estrogen)

  • Heart disease and stroke

  • Osteoporosis and fractures

  • Dementia and Alzheimer’s disease

  • Depression, anxiety, and insomnia

  • Chronic pain and fibromyalgia-like symptoms

  • Increased all-cause mortality

  • Chronic disease


Protective, balanced hormones are one of the most powerful tools we have for long-term health and vitality.


Great News from the FDA


Just this month, on November 10, 2025, after reviewing the latest long-term data, the FDA officially removed the black box warning from bioidentical hormone replacement therapy for menopausal women when used appropriately. This landmark decision acknowledges what progressive providers have known for years: properly dosed bioidentical hormones are safe and dramatically improve quality of life.


Why We Only Use Bioidentical Hormones – Never Synthetics


Synthetic hormones (like Premarin® and Provera®) have a molecular structure foreign to the human body and have been linked to higher risks of blood clots, stroke, and certain cancers. Bioidentical hormones have the exact same chemical structure as the hormones your body produces, so they fit your receptors perfectly and are metabolized naturally.


At Olympic Regenerative Medicine, we never use synthetic hormones – period.


Olympic Regenerative Medicine Logo
Olympic Regenerative Medicine Logo

Meet EvexiPEL – The Gold Standard in Hormone Pellet Therapy


Dr. Cherese Combs, DNP, has been optimizing hormones for over two decades and is a certified EvexiPEL provider. EvexiPEL stands above the crowd because:


  • Pellets are custom-compounded for each patient using only bioidentical estradiol and testosterone.

  • The proprietary delivery method provides steady 24/7 hormone levels – no roller-coaster highs and lows of creams, gels, or pills.

  • Patented pellets include a natural compound that promotes better absorption and longer-lasting results (most patients only need insertion 2–4 times per year).

  • Every batch is third-party tested for potency and purity in an FDA-registered 503B facility.

  • EvexiPEL providers complete rigorous ongoing training to stay at the forefront of hormone science.



The EvexiPEL Method goes even further with a precision dosing algorithm that analyzes over 25 data points from your labs and health history, ensuring your treatment is truly tailored. It may incorporate peptide therapy to boost fat metabolism and tissue repair, plus clinical-grade nutraceuticals to fill nutrient gaps.


This holistic, data-driven approach focuses on whole-body wellness, including nutrition, exercise, and sleep, so you not only relieve symptoms but reclaim your energy, clarity, and confidence. Patients consistently tell us: “This is the first time in years I’ve felt like ME again.”


Learn more about the EvexiPEL difference directly from real patients at evexipel.com/patients.


Personalized Care – Because No Two Bodies Are the Same


There is no one-size-fits-all protocol at Olympic Regenerative Medicine. Dr. Combs reviews your symptoms, lifestyle, complete lab panel, and personal goals to create a plan designed exclusively for you. We monitor your progress closely and fine-tune as needed so you achieve optimal – not just “normal” – levels.



Transparent, Cash-Pay Pricing


We are a cash-pay-only clinic because individually dosed bioidentical hormone pellet therapy (including EvexiPEL) is not FDA-approved as a finished drug product – even though the active ingredients are FDA-approved and the pellets are manufactured in strictly regulated 503B FDA-registered outsourcing facilities.


Insurance companies therefore do not cover the pellet procedure or insertion fees. We keep initial consultation fees low, can provide an itemized receipt with diagnostic codes for possible partial reimbursement of office visits, and gladly accept HSA/FSA cards.


Lab work: You can have your blood drawn at any outside lab your insurance accepts, or use our affordable in-house lab program – typically under $200 for a comprehensive panel that would cost $600+ elsewhere.



Ready to Reclaim Your Vitality?


Are you ready to reclaim your energy, mood, sleep, libido, and confidence? Call Olympic Regenerative Medicine in Sequim today at (360) 602-4010 or visit olyregenmed.com to schedule your consultation.


Life is too short to feel anything less than your absolute best!


Health & Vitality,

Dr. Cherese Combs, DNP

 
 
 

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